I felt I needed to add this section since I know quite a few people who would much rather sketch and ink manually without using the digital tablet...I still do it from time to time infact. The same principles still applies for both.... Unfortunately, you can't really use this method if you plan on coloring the sketch with real media (such as markers or watercolors), but it is useful if you want to display it for online use.

When drawing the initial sketch, it's basically the same for both methods; just try to get the basic proportions correct and don't worry about how messy it is. For the second sketch, instead of creating a new layer in Photoshop, simply redraw the sketch on a separate piece of paper, trying to be more precise. You'd be surprised by this simple act how much the second sketch looks better than the first.

Photoshop is used for the next step. Scan the second sketch in Photoshop so you can rescale it to the largest possible size you can possibly fit onto a piece of paper. (Remember that the larger the outline is, the better it looks when its finished and smaller). An easy way to do this is File> Print with Preview> Check "Scale to Fit Media." Adjust the colors of the sketch to a light sky blue, and print it out for inking. I like to use Sakura Micron pens, ranging in size from .005-.3. Carefully ink over the blue sketch, trying to be as precise as possible, although if you mess up, you can always correct it in Photoshop.